Electronic Theses and Dissertations Uc San Diego Title: Regulation of Target Gene Expression in Sensory Neurons by Brn3a Regulation of Target Gene Expression in Sensory Neurons by Brn3a
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چکیده
.................................................................................. 23 Introduction ............................................................................. 24 Materials and methods ............................................................ 27 Results ..................................................................................... 29 Discussion ............................................................................... 39 Figures..................................................................................... 49 Tables ...................................................................................... 57 References ............................................................................... 62 Acknowledgements ................................................................. 66
منابع مشابه
Coordinated regulation of gene expression by Brn3a in developing sensory ganglia.
Mice lacking the POU-domain transcription factor Brn3a exhibit marked defects in sensory axon growth and abnormal sensory apoptosis. We have determined the regulatory targets of Brn3a in the developing trigeminal ganglion using microarray analysis of Brn3a mutant mice. These results show that Brn3 mediates the coordinated expression of neurotransmitter systems, ion channels, structural componen...
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The TrkA/NGF receptor is essential for the survival and differentiation of sensory neurons. The molecular mechanisms regulating tissue and stage-specific expression of TrkA are largely unknown. The Brn3a POU-domain transcription factor has been implicated in the development of the PNS and proposed as a transcription regulator for TrkA. The molecular mechanisms underlying the regulation of TrkA ...
متن کاملBrn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons.
The POU domain transcription factors Brn3a, Brn3b and Brn3c are required for the proper development of sensory ganglia, retinal ganglion cells, and inner ear hair cells, respectively. We have investigated the roles of Brn3a in neuronal differentiation and target innervation in the facial-stato-acoustic ganglion. We show that absence of Brn3a results in a substantial reduction in neuronal size, ...
متن کاملInteraction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival
The Pit1-Oct1-Unc86 domain (POU domain) transcription factor Brn3a controls sensory neuron survival by regulating the expression of Trk receptors and members of the Bcl-2 family. Loss of Brn3a leads to a dramatic increase in apoptosis and severe loss of neurons in sensory ganglia. Although recent evidence suggests that Brn3a-mediated transcription can be modified by additional cofactors, the ex...
متن کاملDirect autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a.
Brn3a is a POU-domain transcription factor expressed in peripheral sensory neurons and in specific interneurons of the caudal CNS. Sensory expression of Brn3a is regulated by a specific upstream enhancer, the activity of which is greatly increased in Brn3a knockout mice, implying that Brn3a negatively regulates its own expression. Brn3a binds to highly conserved sites within this enhancer, and ...
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تاریخ انتشار 2007